When zebrafish babies are exposed to too much insulin for a long time, their immune system genes become less active - scientists proved this by looking at which genes are turned on or off.

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Evidence from Studies

Supporting (1)

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Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Cross-Sectional Study

Animal

2014 Aug

The study gave zebrafish larvae high amounts of insulin to create a condition called hyperinsulinemia, then looked at which genes were turned on or off. They found that many immune-related genes were turned down (reduced), which exactly matches what the claim says happens.

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Source Study

Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Score: 6

DOI: 10.1530/JOE-14-0178

Similar Assertions

Scientists found that turning off a specific gene called ptpn6 can fix the problems that too much insulin causes in baby zebrafish - specifically, it helps restore their immune system and insulin signaling that get messed up when there's too much insulin.

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