Taking creatine supplements may improve memory in healthy people, and this improvement does not change based on how much is taken, how long it's taken, the person's sex, or where they live.

We analyzed the available evidence and found that 45 studies or assertions suggest creatine supplements may improve memory in healthy people, with no studies contradicting this. The evidence we’ve reviewed so far leans toward the idea that this potential benefit doesn’t depend on how much creatine is taken, how long it’s used, whether the person is male or female, or where they live [1]. This means that across different doses, durations, sexes, and geographic regions, the pattern of memory improvement remains consistent in the studies we’ve seen. We didn’t find any indication that one group responded better or worse than another based on these factors. However, we also note that this conclusion is based on a single assertion that aggregates 45 supporting points — not individual, distinct studies with detailed methods. Because we don’t have access to the original study designs, sample sizes, or how memory was measured in each case, we can’t say whether these findings apply equally to all healthy adults. The consistency across variables is notable, but without more detail, we can’t rule out hidden differences in how the data was collected or grouped. What we’ve found so far suggests creatine might be a reliable factor for memory support in healthy individuals, regardless of typical variables like dosage or sex — but we’re still working with limited structural detail on the underlying research. If you’re considering creatine for memory, the current evidence doesn’t suggest you need to adjust your dose or cycle based on your sex or location — but it’s still early to say this applies universally.