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People with IgA nephropathy who have higher levels of anti–βII-spectrin IgA antibodies also tend to have a higher ratio of IgA to complement C3 in their blood, which is a known indicator of worse...
In people and mice with IgA nephropathy, immune cells that produce IgA antibodies are found inside the kidney tissue itself, where they make antibodies that attack βII-spectrin on kidney cells,...
A protein called βII-spectrin, normally found inside kidney cells, is abnormally exposed on the surface of mesangial cells in people with IgA nephropathy, allowing immune antibodies to bind directly...
In about 60% of people with IgA nephropathy, the immune system produces antibodies that mistakenly bind to a protein called βII-spectrin found on kidney cells, while these antibodies are almost never...
The elderly participants in this study already had higher selenium levels than people in earlier studies where selenium helped thyroid function, which suggests selenium supplements may only help...
In older adults with healthy thyroid function and normal selenium levels, slightly higher selenium levels in the blood are weakly linked to slightly lower T4 and slightly higher T3 relative to T4,...
For healthy older adults in the UK with normal selenium levels, taking selenium supplements daily for six months does not improve how the body converts the thyroid hormone T4 into its more active...
Autoimmune thyroid diseases are far more common in women than men, but among women who develop these diseases, the chance of getting Hashimoto's versus Graves' is about the same.
In areas where drinking water naturally contains high iodine, pregnant women who consume more than 500 micrograms of iodine per day have over four times the rate of thyroid problems compared to those...
In pregnant women, thyroid problems rise sharply only when daily iodine excretion exceeds 450 micrograms; levels between 250 and 450 micrograms do not show increased risk, suggesting there may be a...
People with Hashimoto's thyroiditis tend to have a higher body weight (as measured by BMI) than those with Graves' disease, possibly because low thyroid hormone levels slow metabolism.
In pregnant women exposed to varying levels of iodine, the lowest rate of thyroid problems occurs when daily iodine excretion is between 150 and 250 micrograms, indicating this may be the safest...
Anti-TG antibody levels are about the same in people with Hashimoto's and Graves' disease, so this test cannot help doctors tell which condition a patient has.
Levels of anti-TPO antibodies are similarly high in both Hashimoto's and Graves' disease, so measuring this antibody alone cannot tell doctors which condition a patient has.
Pregnant women who consume 500 micrograms of iodine or more per day have more than four times the rate of thyroid problems compared to those consuming 100 to 200 micrograms per day, suggesting that...
People with Hashimoto's thyroiditis have much higher levels of TSH in their blood than those with Graves' disease, because Hashimoto's causes the thyroid to underproduce hormones, while Graves'...
Pregnant women who consistently consume high amounts of iodine—450 micrograms per day or more—have more than five times the rate of thyroid problems compared to those consuming 150 to 250 micrograms...
In aged human skin cells grown in a lab, two organic forms of selenium—L-hydroxyselenomethionine and Se-methylselenocysteine—work equally well and better than sodium selenite at boosting antioxidant...
In aged human skin cells grown in a lab, two organic forms of selenium—L-hydroxyselenomethionine and Se-methylselenocysteine—boost the production and activity of two key antioxidant enzymes (GPx1 and...
In aged human skin cells grown in a lab, two organic forms of selenium—L-hydroxyselenomethionine and Se-methylselenocysteine—reduce markers of oxidative damage like hydrogen peroxide, lipid...
In aged human skin cells grown in a lab, two organic forms of selenium—Se-methylselenocysteine and L-hydroxyselenomethionine—help restore the balance between active and oxidized glutathione better...
In human skin cells grown in a lab and aged in culture, two forms of organic selenium—L-hydroxyselenomethionine and Se-methylselenocysteine—boost the activity of key antioxidant enzymes and reduce...
High levels of reverse triiodothyronine seen in sick people do not seem to cause the changes in thyroid hormone levels that occur during illness, because giving this molecule to healthy people did...
When people are seriously ill but their thyroid gland is functioning normally, their bodies convert less of the inactive thyroid hormone into the active form in tissues outside the thyroid.