Browse evidence-based analysis of health-related claims and assertions
Taking astaxanthin as a supplement might help your skin hold onto moisture better - one study showed people's skin lost about half less water after taking it, but there wasn't enough research to combine those results together.
Quantitative
A study said astaxanthin might help with skin aging and wrinkles, but the data wasn't strong enough to prove it - the wrinkle reduction result wasn't statistically significant.
A natural red pigment called astaxanthin, found in seafood, might help keep skin looking younger when applied to the skin or taken by mouth, but scientists haven't done good enough studies yet to know for sure.
Descriptive
Scientists looking at studies on astaxanthin for skin aging found that the research so far has problems: the results vary too much between studies, not enough people were tested, and it's hard to tell if the studies were done properly.
Taking astaxanthin supplements (a red-orange antioxidant pigment found in salmon and shrimp) every day for 1-4 months doesn't seem to make wrinkles noticeably shallower in middle-aged people, according to research that combined results from multiple clinical trials.
Taking astaxanthin supplements (a natural red pigment found in salmon and shrimp) every day for 1 to 4 months can make your skin more stretchy and elastic if you're middle-aged and noticing early signs of skin aging.
Taking astaxanthin pills (about 2-12 mg daily for 1-4 months) can help middle-aged people's skin stay more moisturized, according to research combining 5 different experiments.
Causal
A specific part of the DNMT1 protein called the RFTS domain acts like a built-in off switch - it blocks the main part of the protein from attaching to DNA, keeping the enzyme turned off through internal interactions between different parts of the protein.
Mechanistic
Scientists found that one specific genetic change called A554V makes a protein stick to DNA much stronger than other similar genetic changes do - about 8 times stronger compared to only 2.5-3.5 times stronger for the others.
Scientists found that a specific genetic change called A554V makes a small part of a protein slightly less folded, but when they look at just that small part by itself, it looks completely normal.
Scientists found that a small genetic change called A554V makes a protein involved in DNA copying slightly less stable when heated, dropping its stability by about 2 degrees Celsius - but this doesn't happen when they look at just the part of the protein where the change occurs.
A specific genetic change called A554V messes up a natural 'brake' on a protein that copies DNA patterns, making it harder for two parts of that protein to stick together properly.
A specific genetic change called A554V makes a protein that controls DNA tagging work much faster than normal.
Scientists found that a specific genetic change called A554V in a protein called DNMT1 makes it stick to DNA about 8 times tighter than normal.
Scientists are publishing way more papers about resveratrol's potential to fight cancer - there were only about 7 papers in 2003, but by 2022 that number jumped to over 140, which is 20 times more!
The DNA aging test used in the study was reasonably accurate, matching actual age within about 4 years on average
Men taking Rejuvant® for 4-10 months looked about 8.4 years younger biologically, while women looked about 7 years younger on average.
Taking Rejuvant® supplements for longer periods doesn't necessarily mean you'll get more benefits in terms of reducing your biological age - the effect seems to max out after about 7 months.
Correlational
People who looked older than their actual age (based on biological markers) saw bigger improvements in their biological age after taking Rejuvant® supplement, meaning the supplement might work better for people who are aging faster.
Thirteen people who didn't change anything about their lifestyle except taking a supplement called Rejuvant® for about 7 months saw their biological age drop by nearly 8 years on average.
A company studied their supplement Rejuvant® and found that 40 out of 42 people (almost everyone) became biologically younger after taking it for several months.
A study found that adults who took a supplement called Rejuvant® (containing alpha-ketoglutarate and vitamins) for about 7 months had their biological age reduced by an average of 8 years, as measured by a DNA test called TruAge.
Giving female mice a supplement called calcium alpha-ketoglutarate starting in middle age helped them live longer - about 17% longer on average in one group and around 10% longer in another group, with the oldest mice also living longer.
Scientists found that a drug called rapamycin helps mice live longer, but it works better in female mice (14% longer) than in male mice (9% longer). This suggests the drug might affect males and females differently.