Your diet and lifestyle might be quietly calming inflammation — but not all of it works the way you think.

Omega-3s, especially from fish oil, do seem to lower prostaglandin E2 in several studies — even in skin and the colon — though one study found no change despite higher omega-3 levels, so it’s not guaranteed. Anti-inflammatory foods like fatty fish show similar results, likely because they’re rich in those same omega-3s. But when it comes to fiber, stress, and exercise, the evidence is either missing or conflicting: one study found exercise temporarily boosts the very chemical the post says it lowers, and another found no long-term drop in PGE2 among regular exercisers. No research was found linking fiber or stress management to changes in this specific chemical. So while some pieces fit, others are still a mystery.