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Dr. Bill Campbell reveals why consuming 100g of protein in one sitting is failing to build the muscle you expect "The study gave subjects 25 grams of protein or 100 grams of protein immediately after a resistance training workout. When we eat protein, it doesn't all go to muscle. We have something called splanchnic sequestration" "As we get older, this splanchnic sequestration increases so that when we eat protein, more of it is directed to the intestines and organs and does not make it to the blood to go to our muscles" "With the 25 gram dose, I think it was four and a half grams that made it to the skeletal muscles. With the 100 gram dose, it was something like 13 grams out of the 100 that made it to the endpoint of skeletal muscle"

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Science fact-checking

As you age, your gut and liver hoard more of your protein—leaving less for muscles. One study found older adults retain up to 60% more protein in their splanchnic organs than younger ones. So that 100g shake? Much of it never leaves your belly. https://s.fitbodyscience.com/aLMppy

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Scientific verdict4 claims checked

Correlational — new studies may shift this

Links are real but observational — association, not proof of cause.

1Supports
0Challenges
25%Claims hold up
The breakdown

Eating a huge protein shake after a workout might not be the muscle-building hack you think it is.

There’s no direct evidence to back up the exact numbers mentioned—like 4.5 grams or 13 grams making it to muscle—but other research does show that as we age, our digestive organs hold onto more of the protein we eat, leaving less available for muscles. That means even if you down a massive protein shake, your body might not use it the way you expect. The idea that more protein doesn’t always mean more muscle gain isn’t new, but the specific numbers in the post? They’re not backed by any study cited here.

Bottom line

So yeah, loading up on protein might not be the secret sauce—especially as you get older—so maybe spread it out instead of going all-in in one go.

ReliabilityThe evidence mostly supports this with some caveats
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Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.

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