The Study
Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study.
This study gave some women a supplement and others a fake pill, then switched them after a year to see what changed. It found that the supplement seemed to help memory and blood flow in the brain, but we can't be 100% sure because we don't know if everyone stayed blind to what they were taking.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
Scientists tested if taking a daily pill made from grape skin (resveratrol) helps older women think better and improves blood flow to the brain.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 557 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1These changes are small but statistically significant and suggest the supplement may help slow brain aging in older postmenopausal women.
- 2After 2 years, women taking resveratrol scored 33% better on memory and thinking tests, had 27.5% more blood flow in their brain, and had 17.4% lower insulin levels than when they took a placebo.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Related Content
Claims (6)
People who eat diets high in polyphenols have better cognitive function and a lower incidence of cognitive decline with aging.
In postmenopausal women aged 45–85, taking 150 mg of trans-resveratrol daily for two years resulted in a 33% improvement in overall cognitive performance.
In postmenopausal women aged 45–85, taking 150 mg of trans-resveratrol daily for 24 months increased blood flow velocity in the brain by 27.5% and improved the brain's blood vessel response to carbon dioxide and mental tasks.
In postmenopausal women, taking 150 mg of trans-resveratrol daily for two years is associated with less cognitive decline, better blood flow to the brain, and improved insulin sensitivity.
In postmenopausal women aged 45–85, taking 150 mg of trans-resveratrol daily for two years lowered fasting insulin levels by 17.4% and improved the insulin resistance index.
Postmenopausal women aged 65 and older who took 150 mg of trans-resveratrol daily for two years showed better verbal memory than those under 65 who took the same supplement.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.