The Study
Benefits of the Dermocosmetic Mineral 89 Probiotic Fractions Adjunct to Topical Retinoids for Anti-Aging Benefits
This study shows that when people used this cream along with their acne medicine, their skin looked better and felt less irritated after a few months. But it doesn't prove the cream alone caused the improvement — maybe it was just the medicine, or even luck.
Analysis score
Maximum 45 for a randomized controlled trial.
Where the score came from
This study tested a cream called M89PF that’s meant to calm skin when people use a strong acne/anti-aging cream called tretinoin.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 545 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — people felt less pain, their skin looked better, and they reported feeling more confident about their appearance.
- 2After 28 days, the side of the face with the cream had 70% less redness and 11.5% more hydration than the side without it.
- 3After 84 days, stinging dropped by 80% and burning by 64%.
- 4Inflammation markers improved too.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Clinical, Cosmetic and Investigational Dermatology
Year
2023
Authors
Camila Valpaços, S. Leclerc‐Mercier, L. Lopes, Diego Svoboda, Daniel A G Miranda, P. Correia, J. Júnior, É. Fernandes, Véronique François-Newton, Madiiha Bibi Mandary, A. Guéniche, Jerry Tan, D. Kerob
Related Content
Claims (6)
Women aged 44–60 who applied Mineral 89 Probiotic Fractions® twice daily for 28 days while using tretinoin and sunscreen experienced a 70% reduction in facial redness and an 11.5% increase in skin hydration compared to those using only tretinoin and sunscreen. Additional improvements in fine lines, skin tone, radiance, and pore appearance were observed after 84 days.
In women aged 44–60 using topical tretinoin, applying Mineral 89 Probiotic Fractions® for 28 days increased IL-1Ra by 41% and decreased PGE2 by 24% compared to baseline, indicating a measurable reduction in skin inflammation and oxidative stress.
Women aged 44–60 who used Mineral 89 Probiotic Fractions® along with topical tretinoin for 84 days experienced an 80% reduction in self-reported skin stinging and a 64% reduction in burning compared to their symptoms during the first week of treatment.
Women aged 44–60 who used Mineral 89 Probiotic Fractions® along with topical tretinoin for 84 days experienced measurable improvements in their quality of life related to skin appearance and discomfort, as recorded by standardized dermatology questionnaires.
In women aged 44–60 using tretinoin cream, applying Mineral 89 Probiotic Fractions® on one side of the face for 28 days increased skin hydration by 11.5% compared to the untreated side, which showed no change.
Topical retinoids improve the skin's protective barrier, decrease water loss through the skin, and block enzymes that break down collagen and elastin.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.