Blocking insulin signals in the other part of the liver (pericentral zone) cuts down fat buildup in that area without raising blood sugar, even when the mouse eats a high-fat diet.
Scientific Claim
Selective disruption of insulin signaling in pericentral hepatocytes of mice on a high-fat diet reduces fat accumulation specifically in the pericentral zone while maintaining normal blood glucose levels.
Original Statement
“PC-insulin resistance reduced HFD-induced pericentral steatosis while preserving normal glucose homeostasis.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The use of cell-type-specific knockout and direct measurement of zonal steatosis and glucose levels supports definitive language within the context of the mouse model.
Evidence from Studies
Supporting (1)
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
Scientists turned off insulin signaling only in a specific part of the liver in mice eating a high-fat diet, and that reduced fat buildup in that area without raising blood sugar—exactly what the claim says.