Even if you block insulin in the front part of the liver, the mouse still gets high blood sugar when eating a high-fat diet.

Scientific Claim

Disrupting insulin signaling in periportal hepatocytes does not prevent hyperglycemia in mice on a high-fat diet.

Original Statement

“PP-insulin resistance in mice impaired lipogenesis and suppressed high-fat diet (HFD)-induced hepatosteatosis, despite elevating blood glucose and insulin.”

From study:286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

Direct measurement of blood glucose levels under controlled conditions supports a definitive conclusion about the failure to prevent hyperglycemia.

Evidence from Studies

Supporting (0)

No supporting evidence found

Contradicting (1)

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial

Animal

When scientists blocked insulin signaling in a specific part of the liver, the mice’s blood sugar went up—even on a high-fat diet—so blocking this signal doesn’t stop high blood sugar; it makes it worse.

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10

DOI: 10.2337/db25-286-or

Similar Assertions

When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.

94%

Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.

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Blocking insulin signals in the other part of the liver (pericentral zone) cuts down fat buildup in that area without raising blood sugar, even when the mouse eats a high-fat diet.

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The front part of the liver needs insulin to handle sugar properly when eating a high-fat diet—without it, blood sugar rises.

89%

The front part of the liver needs insulin to make fat when the mouse eats a lot of fat—without it, fat production drops.

89%