Even if you block insulin in the front part of the liver, the mouse still gets high blood sugar when eating a high-fat diet.

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286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial

Animal

When scientists blocked insulin signaling in a specific part of the liver, the mice’s blood sugar went up—even on a high-fat diet—so blocking this signal doesn’t stop high blood sugar; it makes it worse.

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10

DOI: 10.2337/db25-286-or

Similar Assertions

When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.

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Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.

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Blocking insulin signals in the other part of the liver (pericentral zone) cuts down fat buildup in that area without raising blood sugar, even when the mouse eats a high-fat diet.

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The front part of the liver needs insulin to handle sugar properly when eating a high-fat diet—without it, blood sugar rises.

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The front part of the liver needs insulin to make fat when the mouse eats a lot of fat—without it, fat production drops.

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