The front part of the liver needs insulin to make fat when the mouse eats a lot of fat—without it, fat production drops.

The front part of the liver needs insulin to handle sugar properly when eating a high-fat diet—without it, blood sugar rises.

When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.

Insulin signals in the back part of the liver help fat build up there when the mouse eats a high-fat diet.

Even if you block insulin in the front part of the liver, the mouse still gets high blood sugar when eating a high-fat diet.

Blocking insulin signals in the other part of the liver (pericentral zone) cuts down fat buildup in that area without raising blood sugar, even when the mouse eats a high-fat diet.