The front part of the liver needs insulin to make fat when the mouse eats a lot of fat—without it, fat production drops.

Scientific Claim

Hepatic insulin signaling in periportal hepatocytes is required for normal lipogenesis during high-fat diet feeding in mice.

Original Statement

“PP-insulin resistance in mice impaired lipogenesis and suppressed high-fat diet (HFD)-induced hepatosteatosis, despite elevating blood glucose and insulin.”

From study:286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The targeted genetic disruption and direct measurement of lipogenesis provide causal evidence within the mouse model, supporting definitive language.

Evidence from Studies

Supporting (0)

No supporting evidence found

Contradicting (1)

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial

Animal

When scientists blocked insulin signals in a specific part of the liver, fat production dropped — meaning those signals are needed to make fat during a high-fat diet.

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10

DOI: 10.2337/db25-286-or

Similar Assertions

The front part of the liver needs insulin to handle sugar properly when eating a high-fat diet—without it, blood sugar rises.

96%

When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.

94%

Insulin signals in the back part of the liver help fat build up there when the mouse eats a high-fat diet.

91%

Even if you block insulin in the front part of the liver, the mouse still gets high blood sugar when eating a high-fat diet.

89%

Blocking insulin signals in the other part of the liver (pericentral zone) cuts down fat buildup in that area without raising blood sugar, even when the mouse eats a high-fat diet.

88%