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Strong Opposition

The front part of the liver needs insulin to handle sugar properly when eating a high-fat diet—without it, blood sugar rises.

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Pro
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Against

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

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Community contributions welcome

10

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial
Animal

When scientists blocked insulin signaling in a specific part of the liver in mice on a high-fat diet, the mice’s blood sugar went up, meaning that part of the liver needs insulin to keep blood sugar normal.

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10
DOI: 10.2337/db25-286-or

Similar Assertions

The front part of the liver needs insulin to make fat when the mouse eats a lot of fat—without it, fat production drops.

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96%

When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.

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93%

Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.

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90%

Insulin signals in the back part of the liver help fat build up there when the mouse eats a high-fat diet.

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90%

Even if you block insulin in the front part of the liver, the mouse still gets high blood sugar when eating a high-fat diet.

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10
89%