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Back to Study: 286-OR: Spatial Regulation of Glucose and Lipid Me...
mechanistic
Analysis v1
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Against

The front part of the liver needs insulin to handle sugar properly when eating a high-fat diet—without it, blood sugar rises.

Scientific Claim

In mice, insulin signaling in periportal hepatocytes is necessary for maintaining normal hepatic glucose metabolism during high-fat diet feeding.

Original Statement

“PP-insulin resistance in mice [...] elevated blood glucose and insulin.”

From study:286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The direct measurement of glucose elevation following targeted disruption supports a definitive mechanistic claim within the mouse model.

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

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286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial
Animal

When scientists blocked insulin signaling in a specific part of the liver in mice on a high-fat diet, the mice’s blood sugar went up, meaning that part of the liver needs insulin to keep blood sugar normal.

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10
DOI: 10.2337/db25-286-or

Similar Assertions

The front part of the liver needs insulin to make fat when the mouse eats a lot of fat—without it, fat production drops.

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When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.

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Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.

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Insulin signals in the back part of the liver help fat build up there when the mouse eats a high-fat diet.

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Even if you block insulin in the front part of the liver, the mouse still gets high blood sugar when eating a high-fat diet.

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