Insulin signals in the back part of the liver help fat build up there when the mouse eats a high-fat diet.
Scientific Claim
In mice, insulin signaling in pericentral hepatocytes contributes to high-fat diet-induced fat accumulation in the pericentral liver zone.
Original Statement
“PC-insulin resistance reduced HFD-induced pericentral steatosis...”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The targeted knockout and direct measurement of zonal steatosis allow definitive conclusions about insulin’s role in promoting pericentral fat accumulation.
Evidence from Studies
Supporting (1)
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
When mice eat a high-fat diet, their liver stores fat, especially in one specific area—pericentral zone. This study found that if you block insulin signals in that area, less fat builds up there, meaning insulin in those liver cells is what helps fat accumulate.