Insulin signals in the back part of the liver help fat build up there when the mouse eats a high-fat diet.

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Evidence from Studies

Supporting (1)

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286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial

Animal

When mice eat a high-fat diet, their liver stores fat, especially in one specific area—pericentral zone. This study found that if you block insulin signals in that area, less fat builds up there, meaning insulin in those liver cells is what helps fat accumulate.

Contradicting (0)

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No contradicting evidence found

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10

DOI: 10.2337/db25-286-or

Similar Assertions

Blocking insulin signals in the other part of the liver (pericentral zone) cuts down fat buildup in that area without raising blood sugar, even when the mouse eats a high-fat diet.

95%

When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.

92%

Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.

91%

The front part of the liver needs insulin to make fat when the mouse eats a lot of fat—without it, fat production drops.

91%

The front part of the liver needs insulin to handle sugar properly when eating a high-fat diet—without it, blood sugar rises.

90%