Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.

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Evidence from Studies

Supporting (1)

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286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial

Animal

When scientists blocked insulin signaling only in a specific part of the liver, the mice still kept their blood sugar normal—even on a high-fat diet—meaning that part of the liver isn’t needed to control blood sugar.

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No contradicting evidence found

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10

DOI: 10.2337/db25-286-or

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