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Back to Study: 286-OR: Spatial Regulation of Glucose and Lipid Me...
descriptive
Analysis v1
10
Pro
0
Against

Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.

Scientific Claim

Disrupting insulin signaling in pericentral hepatocytes does not impair systemic glucose regulation in mice fed a high-fat diet.

Original Statement

“PC-insulin resistance reduced HFD-induced pericentral steatosis while preserving normal glucose homeostasis.”

From study:286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

Direct measurement of glucose homeostasis under controlled conditions supports a definitive conclusion about the absence of glucose dysregulation in this specific context.

Evidence from Studies

Supporting (1)

10
10

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial
Animal

When scientists blocked insulin signaling only in a specific part of the liver, the mice still kept their blood sugar normal—even on a high-fat diet—meaning that part of the liver isn’t needed to control blood sugar.

Contradicting (0)

0
No contradicting evidence found

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10
DOI: 10.2337/db25-286-or

Similar Assertions

Blocking insulin signals in the other part of the liver (pericentral zone) cuts down fat buildup in that area without raising blood sugar, even when the mouse eats a high-fat diet.

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95%

When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.

10
0
92%

Even if you block insulin in the front part of the liver, the mouse still gets high blood sugar when eating a high-fat diet.

0
10
91%

Insulin signals in the back part of the liver help fat build up there when the mouse eats a high-fat diet.

10
0
91%

The front part of the liver needs insulin to handle sugar properly when eating a high-fat diet—without it, blood sugar rises.

0
10
90%