When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.
Scientific Claim
Selective disruption of insulin signaling in periportal hepatocytes of mice on a high-fat diet impairs hepatic lipogenesis and suppresses liver fat accumulation, despite increasing blood glucose and insulin levels.
Original Statement
“PP-insulin resistance in mice impaired lipogenesis and suppressed high-fat diet (HFD)-induced hepatosteatosis, despite elevating blood glucose and insulin.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The study used targeted genetic disruption in a controlled animal model with direct metabolic measurements, allowing definitive statements about the observed effects in mice.
Evidence from Studies
Supporting (1)
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
When scientists blocked insulin signaling in a specific part of the liver in mice eating a high-fat diet, the liver made less fat—even though blood sugar and insulin went up. This matches exactly what the claim says.