Analysis Version
v1
History
Back to Study: PDIA3 rs2788, a risk factor for metabolic syndrome...
descriptive
Analysis v1
59
Pro
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Against

Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene tend to have higher levels of 'bad' cholesterol (LDL) and total cholesterol than those with other versions.

Scientific Claim

In Chinese individuals with metabolic syndrome, the PDIA3 rs2788 GG genotype is associated with higher total cholesterol (4.92 vs 4.68 mmol/L, p=0.025) and LDL cholesterol (3.36 vs 3.20 mmol/L, p=0.043) compared to AA/AG genotypes.

Original Statement

“In the MetS group, but not in the healthy control group, we found that the GG genotype of PDIA3 rs2788 was associated with higher TC and LDL-C levels compared with the AA/GG genotype.”

From study:PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim correctly states association with specific numbers and does not imply causation.

Evidence from Studies

Supporting (1)

59
59

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Case-Control Study
Human
2025 Aug 9

Contradicting (0)

0
No contradicting evidence found

Source Study

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Score: 59
DOI: 10.1038/s41598-025-15075-9

Similar Assertions

For women, having the GG version of the PDIA3 gene is linked to more metabolic syndrome issues, but this isn't the case for men.

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People with a specific version of the PDIA3 gene (GG) are about 1.6 times more likely to have metabolic syndrome than those without it, based on a study of Chinese adults.

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88%

Even after accounting for other metabolic issues, people with the GG version of the PDIA3 gene are about 5 times more likely to have metabolic syndrome.

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84%

Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene have slightly higher triglyceride levels than others, but this difference isn't statistically meaningful.

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83%

People with four metabolic syndrome issues are about 68 times more likely to have the GG version of the PDIA3 gene than those with fewer issues.

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82%