People with a specific version of the PDIA3 gene (GG) are about 1.6 times more likely to have metabolic syndrome than those without it, based on a study of Chinese adults.

Scientific Claim

In Chinese adults, the PDIA3 rs2788 GG genotype is associated with a 1.59-fold higher odds of metabolic syndrome compared to those with AA/AG genotypes (95% confidence interval: 1.01–2.49; p=0.045).

Original Statement

“In the longitudinal analysis, a multivariate logistic regression model adjusted for variable MetS components revealed that PDIA3 rs2788 confers a high risk of MetS incidence (OR: 1.585, 95% CI: 1.011–2.486; p < 0.05).”

From study:PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Evidence Quality Assessment

Claim Status

overstated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study uses 'confers a high risk' which implies causation, but the case-control design only supports association. Corrected to 'associated with higher odds'.

Evidence from Studies

Supporting (1)

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Case-Control Study

Human

2025 Aug 9

Contradicting (0)

No contradicting evidence found

Source Study

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Score: 59

DOI: 10.1038/s41598-025-15075-9

Similar Assertions

Even after accounting for other metabolic issues, people with the GG version of the PDIA3 gene are about 5 times more likely to have metabolic syndrome.

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People with four metabolic syndrome issues are about 68 times more likely to have the GG version of the PDIA3 gene than those with fewer issues.

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For women, having the GG version of the PDIA3 gene is linked to more metabolic syndrome issues, but this isn't the case for men.

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Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene tend to have higher levels of 'bad' cholesterol (LDL) and total cholesterol than those with other versions.

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People with metabolic syndrome are less likely to have the G version of the PDIA3 gene compared to healthy people.

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