Gene variant affects blood pressure and metabolic health
PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Antihypertensive medications are less effective for women with this gene variant, contradicting the assumption that blood pressure drugs work uniformly across all patients.
Most people assume medications work the same for everyone; this shows genetics can drastically alter treatment efficacy.
Practical Takeaways
If you're a woman with uncontrolled hypertension, discuss genetic factors with your doctor—though current evidence isn't strong enough for routine testing.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Antihypertensive medications are less effective for women with this gene variant, contradicting the assumption that blood pressure drugs work uniformly across all patients.
Most people assume medications work the same for everyone; this shows genetics can drastically alter treatment efficacy.
Practical Takeaways
If you're a woman with uncontrolled hypertension, discuss genetic factors with your doctor—though current evidence isn't strong enough for routine testing.
Publication
Journal
Scientific Reports
Year
2025
Authors
Man Zheng, YeTing Li, Lei Gu, ChunYan Xiang, XiaoNing Li, Shanshan Li, Nannan Li, Hongtao Lan, FengLei Zhang
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Claims (10)
Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene have slightly higher triglyceride levels than others, but this difference isn't statistically meaningful.
People with a specific version of the PDIA3 gene (GG) are about 1.6 times more likely to have metabolic syndrome than those without it, based on a study of Chinese adults.
People with the GG version of the PDIA3 gene tend to have higher blood pressure readings—about 5.8 mmHg higher systolic and 4.3 mmHg higher diastolic—compared to those with other versions.
For women taking blood pressure medication, having the GG version of the PDIA3 gene makes the medication work better than expected, reducing the risk of metabolic syndrome components more than just adding up the individual effects.
Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene tend to have higher levels of 'bad' cholesterol (LDL) and total cholesterol than those with other versions.