For women taking blood pressure medication, having the GG version of the PDIA3 gene makes the medication work better than expected, reducing the risk of metabolic syndrome components more than just adding up the individual effects.

Scientific Claim

Among Chinese women, the PDIA3 rs2788 GG genotype shows an antagonistic interaction with antihypertensive treatment, reducing the expected risk of metabolic syndrome components (Synergy Index=0.567, RERI=-0.56; p=0.027).

Original Statement

“In female individuals, the additive interaction was assessed using both the Synergy Index (SI) and the Relative Excess Risk due to Interaction (RERI). The antagonistic effect was consistent across metrics ((p < 0.05, SI = 0.567, RERI = -0.56, Table 8), indicating that the combined exposure had a weaker effect than the sum of individual effects.”

From study:PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Evidence Quality Assessment

Claim Status

overstated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study uses 'interacted negatively' which implies causation, but the design only supports association. Corrected to 'shows an antagonistic interaction' which is appropriate for association.

Evidence from Studies

Supporting (1)

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Case-Control Study

Human

2025 Aug 9

Contradicting (0)

No contradicting evidence found

Source Study

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Score: 59

DOI: 10.1038/s41598-025-15075-9

Similar Assertions

For women, having the GG version of the PDIA3 gene is linked to more metabolic syndrome issues, but this isn't the case for men.

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Over five years, people with the GG version of the PDIA3 gene tend to have slightly higher blood pressure increases than others.

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People with the GG version of the PDIA3 gene tend to have higher blood pressure readings—about 5.8 mmHg higher systolic and 4.3 mmHg higher diastolic—compared to those with other versions.

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Even after accounting for other metabolic issues, people with the GG version of the PDIA3 gene are about 5 times more likely to have metabolic syndrome.

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People with a specific version of the PDIA3 gene (GG) are about 1.6 times more likely to have metabolic syndrome than those without it, based on a study of Chinese adults.

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