For women, having the GG version of the PDIA3 gene is linked to more metabolic syndrome issues, but this isn't the case for men.

Scientific Claim

In Chinese women, the PDIA3 rs2788 GG genotype is associated with a greater number of metabolic syndrome components compared to AA/AG genotypes (p=0.046), but no significant difference was observed in men (p=0.336).

Original Statement

“When stratified by sex, the effect of GG genotype on MetS component number was significantly greater than that of the AA/GA genotype in females (p < 0.05, Table 7) but not in males.”

From study:PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim correctly states association with p-values and specifies sex-specific results without causal language.

Evidence from Studies

Supporting (1)

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Case-Control Study

Human

2025 Aug 9

Contradicting (0)

No contradicting evidence found

Source Study

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Score: 59

DOI: 10.1038/s41598-025-15075-9

Similar Assertions

People with a specific version of the PDIA3 gene (GG) are about 1.6 times more likely to have metabolic syndrome than those without it, based on a study of Chinese adults.

92%

Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene tend to have higher levels of 'bad' cholesterol (LDL) and total cholesterol than those with other versions.

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Even after accounting for other metabolic issues, people with the GG version of the PDIA3 gene are about 5 times more likely to have metabolic syndrome.

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People with four metabolic syndrome issues are about 68 times more likely to have the GG version of the PDIA3 gene than those with fewer issues.

86%

People with metabolic syndrome are less likely to have the G version of the PDIA3 gene compared to healthy people.

86%