People with four metabolic syndrome issues are about 68 times more likely to have the GG version of the PDIA3 gene than those with fewer issues.

Scientific Claim

In Chinese adults, the presence of four metabolic syndrome components is associated with a 67.9-fold higher odds of carrying the PDIA3 rs2788 GG genotype compared to those with fewer components (95% confidence interval: 47.7–96.5; p<0.001).

Original Statement

“Ordered logistic regression revealed that the rs2788 GG genotype was progressive with an increasing number of MetS components (component number: 2–5, both p < 0.05). ... odds ratio of 1.260, 1.294, 7.486, and 67.898, respectively, for 1, 2, 3, and 4 MetS components (both p < 0.05, Table 3).”

From study:PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Evidence Quality Assessment

Claim Status

overstated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study says 'progressive with an increasing number' but the claim correctly uses 'associated with higher odds'.

Evidence from Studies

Supporting (1)

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Case-Control Study

Human

2025 Aug 9

Contradicting (0)

No contradicting evidence found

Source Study

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Score: 59

DOI: 10.1038/s41598-025-15075-9

Similar Assertions

Even after accounting for other metabolic issues, people with the GG version of the PDIA3 gene are about 5 times more likely to have metabolic syndrome.

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People with a specific version of the PDIA3 gene (GG) are about 1.6 times more likely to have metabolic syndrome than those without it, based on a study of Chinese adults.

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For women, having the GG version of the PDIA3 gene is linked to more metabolic syndrome issues, but this isn't the case for men.

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People with metabolic syndrome are less likely to have the G version of the PDIA3 gene compared to healthy people.

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Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene tend to have higher levels of 'bad' cholesterol (LDL) and total cholesterol than those with other versions.

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