People with metabolic syndrome are less likely to have the G version of the PDIA3 gene compared to healthy people.

Scientific Claim

The G allele frequency of PDIA3 rs2788 is significantly lower in Chinese individuals with metabolic syndrome (36.7%) compared to controls (39.6%; p<0.05).

Original Statement

“the frequency of G alleles in the MetS group was significantly lower than that in the control group (χ2 = 4.20; p < 0.05, Table 2).”

From study:PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim correctly states the allele frequency difference without causal language.

Evidence from Studies

Supporting (1)

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Case-Control Study

Human

2025 Aug 9

Contradicting (0)

No contradicting evidence found

Source Study

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Score: 59

DOI: 10.1038/s41598-025-15075-9

Similar Assertions

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For women, having the GG version of the PDIA3 gene is linked to more metabolic syndrome issues, but this isn't the case for men.

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