People with the GG version of the PDIA3 gene tend to have higher blood pressure readings—about 5.8 mmHg higher systolic and 4.3 mmHg higher diastolic—compared to those with other versions.

Scientific Claim

In Chinese adults, the PDIA3 rs2788 GG genotype is associated with 5.82 mmHg higher systolic blood pressure and 4.32 mmHg higher diastolic blood pressure compared to AA/AG genotypes (p<0.01 for both).

Original Statement

“linear regression analysis showed that a positive linear correlation of rs2788 with systolic blood pressure (SBP, β = 5.818, p < 0.01) and diastolic blood pressure (DBP, β = 4.324, p < 0.01).”

From study:PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Evidence Quality Assessment

Claim Status

overstated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study uses 'positive linear correlation' which is correct for association, but the original abstract says 'interacted negatively with antihypertensive medications' which is overstated. However, this specific claim about BP is correctly stated as association.

Evidence from Studies

Supporting (1)

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Case-Control Study

Human

2025 Aug 9

Contradicting (0)

No contradicting evidence found

Source Study

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Score: 59

DOI: 10.1038/s41598-025-15075-9

Similar Assertions

Over five years, people with the GG version of the PDIA3 gene tend to have slightly higher blood pressure increases than others.

96%

People with a specific version of the PDIA3 gene (GG) are about 1.6 times more likely to have metabolic syndrome than those without it, based on a study of Chinese adults.

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For women, having the GG version of the PDIA3 gene is linked to more metabolic syndrome issues, but this isn't the case for men.

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For women taking blood pressure medication, having the GG version of the PDIA3 gene makes the medication work better than expected, reducing the risk of metabolic syndrome components more than just adding up the individual effects.

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Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene tend to have higher levels of 'bad' cholesterol (LDL) and total cholesterol than those with other versions.

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