Over five years, people with the GG version of the PDIA3 gene tend to have slightly higher blood pressure increases than others.

Scientific Claim

In Chinese adults followed for five years, the PDIA3 rs2788 GG genotype is associated with a 0.304 mmHg increase in systolic blood pressure change per unit genotype (β=0.304, p<0.001).

Original Statement

“Linear regressions analysis of ΔSBP and ΔDBP after five years. PDIA3 rs2788 β = 0.304 < 0.001”

From study:PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Evidence Quality Assessment

Claim Status

overstated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study uses 'strong association' but the claim correctly states association with β coefficient.

Evidence from Studies

Supporting (1)

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Case-Control Study

Human

2025 Aug 9

Contradicting (0)

No contradicting evidence found

Source Study

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Score: 59

DOI: 10.1038/s41598-025-15075-9

Similar Assertions

People with the GG version of the PDIA3 gene tend to have higher blood pressure readings—about 5.8 mmHg higher systolic and 4.3 mmHg higher diastolic—compared to those with other versions.

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For women taking blood pressure medication, having the GG version of the PDIA3 gene makes the medication work better than expected, reducing the risk of metabolic syndrome components more than just adding up the individual effects.

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People with a specific version of the PDIA3 gene (GG) are about 1.6 times more likely to have metabolic syndrome than those without it, based on a study of Chinese adults.

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Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene have slightly higher triglyceride levels than others, but this difference isn't statistically meaningful.

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Even after accounting for other metabolic issues, people with the GG version of the PDIA3 gene are about 5 times more likely to have metabolic syndrome.

75%