Analysis Version
v1
History
Back to Study: PDIA3 rs2788, a risk factor for metabolic syndrome...
descriptive
Analysis v1
59
Pro
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Against

Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene have slightly higher triglyceride levels than others, but this difference isn't statistically meaningful.

Scientific Claim

In Chinese adults, the PDIA3 rs2788 GG genotype is associated with higher triglyceride levels (2.31 vs 2.29 mmol/L, p=0.898) in the MetS group, though this difference was not statistically significant.

Original Statement

“TG (mmol/L) 0.91 ± 0.31 0.90 ± 0.30 0.436 2.29 ± 1.46 2.31 ± 1.59 0.898”

From study:PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim correctly states the lack of statistical significance and does not overstate the finding.

Evidence from Studies

Supporting (1)

59
59

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Case-Control Study
Human
2025 Aug 9

Contradicting (0)

0
No contradicting evidence found

Source Study

PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Score: 59
DOI: 10.1038/s41598-025-15075-9

Similar Assertions

Chinese people with metabolic syndrome who have the GG version of the PDIA3 gene tend to have higher levels of 'bad' cholesterol (LDL) and total cholesterol than those with other versions.

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83%

People with a specific version of the PDIA3 gene (GG) are about 1.6 times more likely to have metabolic syndrome than those without it, based on a study of Chinese adults.

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80%

Even after accounting for other metabolic issues, people with the GG version of the PDIA3 gene are about 5 times more likely to have metabolic syndrome.

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79%

For women, having the GG version of the PDIA3 gene is linked to more metabolic syndrome issues, but this isn't the case for men.

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79%

People with the GG version of the PDIA3 gene tend to have higher blood pressure readings—about 5.8 mmHg higher systolic and 4.3 mmHg higher diastolic—compared to those with other versions.

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77%