When your body breaks down fructose, it can create more uric acid, which might make your blood vessels less able to relax and widen because of lower levels of a helpful substance called nitric oxide.

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Evidence from Studies

Supporting (1)

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Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis

Cross-Sectional Study

Animal

2014 Jul

The study shows that high uric acid levels harm blood vessel function by reducing nitric oxide, which helps blood vessels relax. This matches part of the claim, but the study didn’t look at fructose itself.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Similar Assertions

Fructose metabolism in the liver produces uric acid, which impairs endothelial function by reducing nitric oxide availability and arterial relaxation.

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Eating too much fructose, like the sugar in soda and candy, can raise a substance in your blood called uric acid, which may damage your blood vessels and raise your blood pressure, making your heart more at risk.

1

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82%

Eating too much fructose, like the sugar in soda and candy, can raise a substance in your blood called uric acid, which may damage your blood vessels and raise your blood pressure, making heart disease more likely.

1

0

82%

Eating too much fructose—like the sugar in soda and candy—can raise a substance in your blood called uric acid, which may damage your blood vessels, raise your blood pressure, and cause body-wide inflammation, all of which can lead to heart disease.

1

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75%

Eating fructose (like table sugar) led to higher uric acid levels in rats compared to other sugars. This finding is from the abstract summary - full study details were not available

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73%