Giving leptin to mice raises their leptin hormone levels to about 80 ng/ml, regardless of whether they have leptin receptors in certain brain cells.

Scientific Claim

Leptin infusion increases plasma leptin levels to approximately 80 ng/ml in both control mice and mice with leptin receptor deletion in proopiomelanocortin neurons.

Original Statement

“Leptin infusion in WT mice caused marked reduction in plasma glucose and insulin levels, whereas leptin failed to reduce plasma glucose or insulin levels in LepRflox/flox/POMC-Cre mice. Leptin increased plasma leptin levels in WT and LepRflox/flox/POMC-Cre mice from 3.5 ± 0.9 to 80.2 ± 8.5 and 9.2 ± 1.0 to 82.2 ± 2.0 ng/ml, respectively.”

From study:Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims; 'increases' correctly describes the observed change without causal inference.

Evidence from Studies

Supporting (1)

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

Contradicting (0)

No contradicting evidence found

Source Study

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Score: 14

DOI: 10.1161/HYPERTENSIONAHA.110.161349

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