Leptin reduces eating in both normal mice and those missing leptin receptors in certain brain cells, meaning these brain cells aren't needed for leptin's appetite control.

Scientific Claim

Chronic leptin infusion reduces food intake by approximately 28-35% in both control mice and mice with leptin receptor deletion in proopiomelanocortin neurons, indicating proopiomelanocortin neurons may not be essential for this effect.

Original Statement

“Chronic i.v. infusion of leptin for 7 consecutive days markedly reduced food intake in WT, LepRflox/flox and LepRflox/flox/POMC-Cre mice (Figure 3B).”

From study:Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims; 'indicating' appropriately reflects the inferred mechanism without causal language.

Evidence from Studies

Supporting (1)

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

Contradicting (0)

No contradicting evidence found

Source Study

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Score: 14

DOI: 10.1161/HYPERTENSIONAHA.110.161349

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