Leptin makes both normal mice and those missing leptin receptors in certain brain cells burn more oxygen, meaning this effect works through other brain pathways.

Scientific Claim

Leptin increases oxygen consumption in both control mice and mice with leptin receptor deletion in proopiomelanocortin neurons, suggesting this effect does not depend on proopiomelanocortin neurons.

Original Statement

“Leptin increased oxygen consumption in LepRflox/flox/POMC-Cre and wild-type mice.”

From study:Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims; 'suggests' appropriately reflects the inferred mechanism without causal language.

Evidence from Studies

Supporting (1)

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

Contradicting (0)

No contradicting evidence found

Source Study

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Score: 14

DOI: 10.1161/HYPERTENSIONAHA.110.161349

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