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Back to Study: Control of Blood Pressure, Appetite, and Glucose b...
descriptive
Analysis v1
14
Pro
0
Against

Leptin lowers blood sugar and insulin in normal mice, but not in mice missing leptin receptors in certain brain cells.

Scientific Claim

Leptin infusion reduces plasma glucose and insulin levels in control mice but not in mice with leptin receptor deletion in proopiomelanocortin neurons.

Original Statement

“Leptin significantly decreased insulin and glucose levels in control mice but not in LepRflox/flox/POMC-Cre mice.”

From study:Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims; 'reduces' is appropriate for observed differences without causal inference.

Evidence from Studies

Supporting (1)

14
14

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial
Animal
2011 May

Contradicting (0)

0
No contradicting evidence found

Source Study

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Score: 14
DOI: 10.1161/HYPERTENSIONAHA.110.161349

Similar Assertions

Giving leptin to mice raises their leptin hormone levels to about 80 ng/ml, regardless of whether they have leptin receptors in certain brain cells.

14
0
92%

When mice lack leptin receptors in certain brain cells, they become heavier, have higher blood sugar, more insulin, and more leptin hormone than normal mice.

14
0
88%

Leptin reduces eating in both normal mice and those missing leptin receptors in certain brain cells, meaning these brain cells aren't needed for leptin's appetite control.

14
0
85%

When mice lack leptin receptors in certain brain cells, giving them leptin slightly lowers their blood pressure instead of raising it like in normal mice.

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0
84%

Leptin doesn't change how well mice with missing leptin receptors in certain brain cells regulate their blood pressure through reflexes.

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0
82%