Leptin doesn't change how well mice with missing leptin receptors in certain brain cells regulate their blood pressure through reflexes.

Scientific Claim

Mice with leptin receptor deletion in proopiomelanocortin neurons show no significant change in spontaneous baroreflex sensitivity during chronic leptin infusion.

Original Statement

“Spontaneous BRS were analyzed by time and frequency domains... chronic leptin infusion for 7 days did not alter spontaneous BRS in either group.”

From study:Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims; 'show no significant change' correctly describes the observed null result without causal language.

Evidence from Studies

Supporting (1)

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

Contradicting (0)

No contradicting evidence found

Source Study

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Score: 14

DOI: 10.1161/HYPERTENSIONAHA.110.161349

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