Mice missing leptin receptors in certain brain cells have blood pressure like mice with floxed leptin receptors but lower than normal mice.

Scientific Claim

Baseline mean arterial pressure in mice with leptin receptor deletion in proopiomelanocortin neurons is similar to LepRflox/flox control mice but lower than wild-type mice.

Original Statement

“LepRflox/flox/POMC-Cre mice had normal MAP and heart rate compared with LepRflox/flox but lower MAP and heart rate compared with wild-type mice.”

From study:Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims; 'is similar to' and 'lower than' correctly describe observed differences without causal language.

Evidence from Studies

Supporting (1)

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

Contradicting (0)

No contradicting evidence found

Source Study

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Score: 14

DOI: 10.1161/HYPERTENSIONAHA.110.161349

Similar Assertions

When mice lack leptin receptors in certain brain cells, giving them leptin slightly lowers their blood pressure instead of raising it like in normal mice.

92%

Mice missing leptin receptors in certain brain cells have weaker blood pressure and heart rate reactions to sudden stress compared to normal mice.

86%

Leptin doesn't change how well mice with missing leptin receptors in certain brain cells regulate their blood pressure through reflexes.

82%

When mice lack leptin receptors in certain brain cells, they become heavier, have higher blood sugar, more insulin, and more leptin hormone than normal mice.

81%

Giving leptin to mice raises their leptin hormone levels to about 80 ng/ml, regardless of whether they have leptin receptors in certain brain cells.

78%