Mice missing leptin receptors in certain brain cells have weaker blood pressure and heart rate reactions to sudden stress compared to normal mice.

Scientific Claim

Mice with leptin receptor deletion in proopiomelanocortin neurons exhibit impaired blood pressure and heart rate responses to acute stress compared to wild-type mice.

Original Statement

“LepRflox/flox/POMC-Cre mice also exhibited impaired MAP and HR responses to acute stress (Figures 5A, 5B and 5C), suggesting that these animals not only have lower baseline MAP and HR compared to control mice, but may also be resistant to hypertensive stimuli such as air-jet stress.”

From study:Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims; 'exhibit impaired' correctly describes observed differences without causal inference.

Evidence from Studies

Supporting (1)

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

Contradicting (0)

No contradicting evidence found

Source Study

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Score: 14

DOI: 10.1161/HYPERTENSIONAHA.110.161349

Similar Assertions

Mice missing leptin receptors in certain brain cells have blood pressure like mice with floxed leptin receptors but lower than normal mice.

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When mice lack leptin receptors in certain brain cells, giving them leptin slightly lowers their blood pressure instead of raising it like in normal mice.

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When mice lack leptin receptors in certain brain cells, they become heavier, have higher blood sugar, more insulin, and more leptin hormone than normal mice.

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Leptin doesn't change how well mice with missing leptin receptors in certain brain cells regulate their blood pressure through reflexes.

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