When mice lack leptin receptors in certain brain cells, giving them leptin slightly lowers their blood pressure instead of raising it like in normal mice.
Scientific Claim
Chronic leptin infusion in mice with leptin receptor deletion in proopiomelanocortin neurons is associated with a non-significant reduction in mean arterial pressure of approximately 3 mmHg, whereas in control mice it is associated with a significant increase of approximately 5 mmHg.
Original Statement
“In control mice, leptin increased MAP by ≈5 mm Hg despite decreasing food intake by ≈35%. In contrast, leptin infusion in LepRflox/flox/POMC-Cre mice reduced MAP by ≈3 mm Hg and food intake by ≈28%.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design supports association claims; 'associated with' correctly describes the observed differences without implying causation.
Evidence from Studies
Supporting (1)
Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons