When mice lack leptin receptors in certain brain cells, giving them leptin slightly lowers their blood pressure instead of raising it like in normal mice.

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims; 'associated with' correctly describes the observed differences without implying causation.

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

No contradicting evidence found

Mice missing leptin receptors in certain brain cells have blood pressure like mice with floxed leptin receptors but lower than normal mice.

92%

Giving leptin to mice raises their leptin hormone levels to about 80 ng/ml, regardless of whether they have leptin receptors in certain brain cells.

87%

Mice missing leptin receptors in certain brain cells have weaker blood pressure and heart rate reactions to sudden stress compared to normal mice.

86%

Leptin doesn't change how well mice with missing leptin receptors in certain brain cells regulate their blood pressure through reflexes.

85%

Leptin lowers blood sugar and insulin in normal mice, but not in mice missing leptin receptors in certain brain cells.

84%