When mice lack leptin receptors in certain brain cells, they become heavier, have higher blood sugar, more insulin, and more leptin hormone than normal mice.

Scientific Claim

Deletion of leptin receptors in proopiomelanocortin neurons in mice is associated with increased body weight, hyperglycemia, hyperinsulinemia, and hyperleptinemia compared to control mice.

Original Statement

“LepRflox/flox/POMC-Cre mice were heavier, hyperglycemic, hyperinsulinemic, and hyperleptinemic compared with wild-type, LepRflox/flox, and POMC-Cre mice.”

From study:Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is an observational animal cohort, so 'associated with' correctly reflects the correlational nature without implying causation.

Evidence from Studies

Supporting (1)

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

Contradicting (0)

No contradicting evidence found

Source Study

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Score: 14

DOI: 10.1161/HYPERTENSIONAHA.110.161349

Similar Assertions

Leptin lowers blood sugar and insulin in normal mice, but not in mice missing leptin receptors in certain brain cells.

88%

Mice missing leptin receptors in certain brain cells have twice as much belly fat as normal mice.

86%

Leptin doesn't change how well mice with missing leptin receptors in certain brain cells regulate their blood pressure through reflexes.

83%

When mice lack leptin receptors in certain brain cells, giving them leptin slightly lowers their blood pressure instead of raising it like in normal mice.

82%

Giving leptin to mice raises their leptin hormone levels to about 80 ng/ml, regardless of whether they have leptin receptors in certain brain cells.

82%