Mice missing leptin receptors in certain brain cells have twice as much belly fat as normal mice.

Scientific Claim

Mice with leptin receptor deletion in proopiomelanocortin neurons have approximately double the epididymal fat mass compared to control mice.

Original Statement

“The increased body weight in LepRflox/flox/POMC-Cre mice was associated with almost a doubling of epididymal fat mass (Table 1).”

From study:Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims; 'have approximately double' correctly describes the observed difference without causal inference.

Evidence from Studies

Supporting (1)

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

Contradicting (0)

No contradicting evidence found

Source Study

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Score: 14

DOI: 10.1161/HYPERTENSIONAHA.110.161349

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