Mice given MOTS-c had higher levels of the peptide in their blood compared to those without treatment.

Mice with immobilized legs that received MOTS-c had lower levels of key inflammation markers in their blood compared to untreated mice.

MOTS-c treatment lowered levels of myostatin, a protein that normally limits muscle growth, in immobilized mice.

When mice had their legs immobilized for 8 days, giving them MOTS-c daily helped their muscles lose less weight—only 5% compared to 15% without treatment.

MOTS-c treatment reduced collagen buildup in the muscles of immobilized mice, which may help prevent stiffness.

MOTS-c reduced levels of several inflammatory proteins in the blood of immobilized mice, which may help reduce muscle damage.