Mice given MOTS-c had higher levels of the peptide in their blood compared to those without treatment.
Scientific Claim
In male C57BL/6J mice with 8 days of hindlimb immobilization, daily intraperitoneal administration of MOTS-c (15 mg/kg/day) was associated with significantly increased plasma MOTS-c levels compared to untreated controls.
Original Statement
“Eight days of MOTS-c administration significantly increased plasma levels of MOTS-c (Fig. 2A).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim uses 'was associated with significantly increased' which accurately reflects the study's measurement of plasma levels.
Evidence from Studies
Supporting (1)
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.