MOTS-c reduced levels of several inflammatory proteins in the blood of immobilized mice, which may help reduce muscle damage.

Mice with immobilized legs that received MOTS-c had lower levels of key inflammation markers in their blood compared to untreated mice.

MOTS-c treatment lowered levels of myostatin, a protein that normally limits muscle growth, in immobilized mice.

Mice given MOTS-c had higher levels of the peptide in their blood compared to those without treatment.

MOTS-c lowered levels of myostatin, a protein that inhibits muscle growth, in the muscles of immobilized mice.

When mice had their legs immobilized for 8 days, giving them MOTS-c helped their muscles lose less weight (5% instead of 15%) compared to mice that didn't get the treatment.