MOTS-c helped restore normal activity levels of key muscle proteins (AKT and FOXOs) that are disrupted during immobilization.

Scientific Claim

In male C57BL/6J mice subjected to 8 days of hindlimb immobilization, daily MOTS-c administration (15 mg/kg/day) was associated with normalized phosphorylation levels of AKT (Ser473), FOXO1 (Ser256), and FOXO3a (Ser253) compared to untreated controls.

Original Statement

“MOTS-c administration restored the decrease in phosphorylation of AKT at Ser 473 (P < 0.01), FOXO1 at Ser 256 (P < 0.05), and FOXO3a at Ser 253 (P < 0.01) that was observed in the cast immobilization control group.”

From study:Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports association claims. The claim uses 'was associated with' and specifies the molecular targets without causal language.

Evidence from Studies

Supporting (1)

Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

Randomized Controlled Trial

Animal

2024 Mar 1

Contradicting (0)

No contradicting evidence found

Source Study

Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

Score: 16

DOI: 10.1152/ajpendo.00285.2023

Similar Assertions

MOTS-c helped maintain higher activity levels of key muscle signaling proteins (AKT, FOXO1, FOXO3a) in immobilized mice, which are important for muscle health.

92%

MOTS-c treatment lowered levels of myostatin, a protein that normally limits muscle growth, in immobilized mice.

79%

Mice with immobilized legs that received MOTS-c had lower levels of key inflammation markers in their blood compared to untreated mice.

77%

MOTS-c reduced the amount of fatty acids in the muscles of immobilized mice, which may prevent harmful fat buildup.

74%

When mice had their legs immobilized for 8 days, giving them MOTS-c helped their muscles lose less weight (5% instead of 15%) compared to mice that didn't get the treatment.

73%