The liver isn’t the same all the way through—different parts react differently when insulin stops working, leading to very different outcomes for fat and sugar.

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Evidence from Studies

Supporting (1)

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286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial

Animal

The liver has two main zones, and when insulin doesn’t work well in each zone, they react differently—one makes less fat but raises blood sugar, the other reduces fat without affecting blood sugar. This proves the liver’s layout matters for how it responds to insulin problems.

Contradicting (0)

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No contradicting evidence found

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10

DOI: 10.2337/db25-286-or

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