The liver isn’t the same all the way through—different parts react differently when insulin stops working, leading to very different outcomes for fat and sugar.
Scientific Claim
The liver’s spatial organization into periportal and pericentral zones results in distinct metabolic responses to insulin resistance in mice.
Original Statement
“These results demonstrate distinct roles of insulin in PP versus PC.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The experimental design directly tested and compared two spatially defined cell populations, providing robust evidence for zone-specific roles of insulin.
Evidence from Studies
Supporting (1)
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
The liver has two main zones, and when insulin doesn’t work well in each zone, they react differently—one makes less fat but raises blood sugar, the other reduces fat without affecting blood sugar. This proves the liver’s layout matters for how it responds to insulin problems.