Turning off insulin signals in the back part of the liver cuts fat without making the body pump out more insulin.
Scientific Claim
In mice, pericentral insulin resistance does not increase systemic insulin levels despite reducing liver fat.
Original Statement
“PC-insulin resistance reduced HFD-induced pericentral steatosis while preserving normal glucose homeostasis.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The absence of reported hyperinsulinemia in PC-insulin resistance, contrasted with its presence in PP, supports a definitive claim of differential systemic effects.
Evidence from Studies
Supporting (1)
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
In mice, blocking insulin signaling in a specific part of the liver reduces fat buildup there but doesn’t raise insulin levels in the blood—unlike blocking it in other parts, which does raise insulin.