When the front part of the liver doesn’t respond to insulin, the body makes more insulin to try to compensate.

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Evidence from Studies

Supporting (1)

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286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial

Animal

When liver cells near the entrance (periportal) stop responding to insulin, the body makes more insulin to compensate, even in mice eating a high-fat diet.

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No contradicting evidence found

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10

DOI: 10.2337/db25-286-or

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