When the front part of the liver can't respond to insulin, blood sugar goes up—even if the liver makes less fat.

When the front part of the liver doesn’t respond to insulin, the body makes more insulin to try to compensate.

When the part of the liver that usually responds to insulin is blocked, the liver makes less fat even when the mouse eats a high-fat diet—but its blood sugar and insulin go up instead.

Even if you block insulin in the front part of the liver, the mouse still gets high blood sugar when eating a high-fat diet.

The front part of the liver needs insulin to handle sugar properly when eating a high-fat diet—without it, blood sugar rises.

Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.