When insulin doesn’t work in the back part of the liver, the body doesn’t respond by making more insulin—even though fat in the liver goes down.
Scientific Claim
Pericentral insulin resistance in mice does not lead to compensatory hyperinsulinemia despite reducing liver fat.
Original Statement
“PC-insulin resistance reduced HFD-induced pericentral steatosis while preserving normal glucose homeostasis.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The study reports insulin levels only in the context of PP-insulin resistance; the lack of mention in PC group, combined with preserved glucose, supports a definitive inference of no hyperinsulinemia.
Evidence from Studies
Supporting (1)
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
When insulin signaling is blocked only in the center part of the liver in mice, their liver fat goes down but their blood sugar and insulin levels stay normal—meaning the body doesn’t panic and pump out extra insulin.