When insulin doesn’t work in the back part of the liver, the body doesn’t respond by making more insulin—even though fat in the liver goes down.

Turning off insulin signals in the back part of the liver cuts fat without making the body pump out more insulin.

When the front part of the liver doesn’t respond to insulin, the body makes more insulin to try to compensate.

When the front part of the liver can't respond to insulin, blood sugar goes up—even if the liver makes less fat.

Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.

When insulin doesn't work in the back part of the liver, the muscles start using more sugar instead, which helps keep blood sugar levels normal.