Analysis Version
v1
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Back to Study: 286-OR: Spatial Regulation of Glucose and Lipid Me...
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Analysis v1
Strong Support

When insulin doesn’t work in the back part of the liver, the body doesn’t respond by making more insulin—even though fat in the liver goes down.

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Pro
0
Against

Evidence from Studies

Supporting (1)

10

Community contributions welcome

10

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial
Animal

When insulin signaling is blocked only in the center part of the liver in mice, their liver fat goes down but their blood sugar and insulin levels stay normal—meaning the body doesn’t panic and pump out extra insulin.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10
DOI: 10.2337/db25-286-or

Similar Assertions

Turning off insulin signals in the back part of the liver cuts fat without making the body pump out more insulin.

10
0
90%

When the front part of the liver doesn’t respond to insulin, the body makes more insulin to try to compensate.

10
0
79%

When the front part of the liver can't respond to insulin, blood sugar goes up—even if the liver makes less fat.

10
0
78%

Turning off insulin signals in the back part of the liver doesn’t make blood sugar go up, even when the mouse eats a high-fat diet.

10
0
74%

When insulin doesn't work in the back part of the liver, the muscles start using more sugar instead, which helps keep blood sugar levels normal.

10
0
73%