When insulin doesn't work in the back part of the liver, the muscles start using more sugar instead, which helps keep blood sugar levels normal.

Turning off insulin signals in the back part of the liver cuts fat without making the body pump out more insulin.

When the front part of the liver can't respond to insulin, blood sugar goes up—even if the liver makes less fat.

When insulin doesn’t work in the back part of the liver, the body doesn’t respond by making more insulin—even though fat in the liver goes down.

Where in the liver insulin resistance happens determines whether it causes high blood sugar, high fat, or neither.

When the front part of the liver doesn’t respond to insulin, the body makes more insulin to try to compensate.