When insulin doesn't work in the back part of the liver, the muscles start using more sugar instead, which helps keep blood sugar levels normal.

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Evidence from Studies

Supporting (1)

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286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial

Animal

When insulin doesn’t work well in a specific part of the liver (the pericentral zone), the body compensates by using muscles instead of the liver to process sugar, which keeps blood sugar levels normal — even though the liver isn’t doing its usual job.

Contradicting (0)

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No contradicting evidence found

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10

DOI: 10.2337/db25-286-or

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