When insulin doesn't work in the back part of the liver, the muscles start using more sugar instead, which helps keep blood sugar levels normal.
Scientific Claim
In mice with pericentral insulin resistance, glycolytic metabolism shifts from the liver to skeletal muscle, contributing to preserved glucose homeostasis.
Original Statement
“Conversely, PC-insulin resistance reduced HFD-induced pericentral steatosis while preserving normal glucose homeostasis, in part by shifting glycolytic metabolism from the liver to muscle.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The study directly measured metabolic shifts between tissues using established methods in a controlled model, justifying definitive language about the observed redistribution.
Evidence from Studies
Supporting (1)
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
When insulin doesn’t work well in a specific part of the liver (the pericentral zone), the body compensates by using muscles instead of the liver to process sugar, which keeps blood sugar levels normal — even though the liver isn’t doing its usual job.