Where in the liver insulin resistance happens determines whether it causes high blood sugar, high fat, or neither.
Scientific Claim
The metabolic effects of hepatic insulin resistance in mice are dependent on the spatial location of the affected hepatocytes.
Original Statement
“These results demonstrate distinct roles of insulin in PP versus PC.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The experimental design isolates and compares two anatomical zones with direct metabolic readouts, providing definitive evidence for spatial dependency.
Evidence from Studies
Supporting (1)
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
The study found that when insulin resistance happens in different parts of the liver, it causes different problems—like high blood sugar in one area and fat buildup in another—proving that where in the liver the problem occurs matters a lot.