Where in the liver insulin resistance happens determines whether it causes high blood sugar, high fat, or neither.

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Evidence from Studies

Supporting (1)

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286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Randomized Controlled Trial

Animal

The study found that when insulin resistance happens in different parts of the liver, it causes different problems—like high blood sugar in one area and fat buildup in another—proving that where in the liver the problem occurs matters a lot.

Contradicting (0)

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No contradicting evidence found

Source Study

286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling

Score: 10

DOI: 10.2337/db25-286-or

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