When mice eat a high-fat diet, fat builds up in both parts of the liver—but blocking insulin in just one part stops fat from building up there.
Scientific Claim
High-fat diet induces fat accumulation in both periportal and pericentral zones of the liver in control mice, but this is selectively reduced by zone-specific insulin signaling disruption.
Original Statement
“PP-insulin resistance [...] suppressed high-fat diet (HFD)-induced hepatosteatosis [...] PC-insulin resistance reduced HFD-induced pericentral steatosis.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The study directly compared steatosis in control and genetically modified mice under HFD, supporting definitive claims about zonal fat accumulation and reduction.
Evidence from Studies
Supporting (1)
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
The study found that when mice eat a high-fat diet, fat builds up in two parts of the liver—but if you block insulin signaling in just one part, less fat builds up there, without messing up blood sugar. So yes, turning off insulin in specific liver zones can reduce fat in just those spots.