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Among overweight or obese teenage girls who skip breakfast, eating a high-protein breakfast does not lead to a lower total calorie intake over the day, because they tend to eat more later to make up...
Among overweight or obese teenage girls who typically skip breakfast, eating a breakfast high in protein leads to about a 25% reduction in evening consumption of high-fat snacks, even when total...
For overweight or obese teenage girls, eating breakfast—whether high-protein or normal-protein—lowers hunger and increases fullness during the day compared to skipping breakfast. A high-protein...
In overweight or obese teenage girls who skip breakfast, eating a meal with 35 grams of protein before lunch leads to less brain activity in regions linked to food motivation when shown food images,...
Among overweight or obese adolescent girls who skip breakfast, eating a morning meal with 35 grams of protein from eggs and beef reduces hunger, increases fullness, alters hunger-related hormones,...
After losing weight, people who eat more and move more may experience a lower biological urge to regain weight because their metabolism stays higher and they feel less hungry, but it is not known...
After losing weight, obese adults who experience a high energy flux—meaning they eat and burn a lot of calories—do not show different changes in calorie burning after eating or in blood sugar and...
In people who have lost weight and are obese, engaging in daily exercise that burns about 500 calories while eating more food leads to a small increase in resting metabolism and changes in hunger and...
In human muscle precursor cells grown in the lab, a compound called oleuropein aglycone increases markers of autophagy—cellular cleanup processes—to the same extent as rapamycin, a known trigger of...
In human muscle precursor cells exposed to oxidative stress, oleuropein aglycone alters the phosphorylation state of the FOXO3a protein at two specific sites, which is associated with increased...
In human muscle precursor cells grown in the lab, a compound called oleuropein aglycone causes a short-lived rise and fall in a specific cellular energy sensor (AMPK) within hours, while other...
In human muscle cells grown in the lab, a compound called oleuropein aglycone at a concentration of 25 micromolar, applied for 24 hours, increases the activity of genes involved in antioxidant...
In human muscle cells exposed to a damaging chemical, pre-treatment with a compound called oleuropein aglycone reduced markers of oxidative stress and cellular aging, suggesting it may help protect...
Oleuropein aglycone triggers a cellular cleanup process called autophagy in human neuroblastoma cells, and part of this effect requires AMPK activity. When AMPK is blocked, autophagy decreases but...
In mice genetically engineered to develop amyloid-beta plaques, a daily dose of oleuropein aglycone for eight weeks was associated with decreased activity of mTOR and p70 S6K proteins and increased...
Blocking the CAMKKβ protein stops oleuropein aglycone from activating AMPK and triggering autophagy in human neuroblastoma cells, showing that CAMKKβ is required for this biological process to occur.
In human neuroblastoma cells, a compound called oleuropein aglycone causes two distinct rises in calcium levels inside the cell—one at 10 minutes and another between 1 and 2 hours—by releasing...
Oleuropein aglycone, a compound found in olives, triggers a sequence of molecular events in human nerve cancer cells and mouse brain tissue that leads to the formation of cellular structures involved...
When lean men eat less protein and replace it with carbs, their bodies become more sensitive to insulin, but replacing protein with fat does not have this effect.
When male mice are fed a low-protein diet, their fat tissue undergoes changes in mitochondrial function, but these changes do not occur if the mice lack the FGF21 protein, showing that FGF21 is...
In lean men, reducing protein intake alters mitochondrial proteins in fat tissue, increasing some components involved in energy production while decreasing others, which may lead to higher energy use.
When lean men reduce their dietary protein intake, their blood levels of a signaling molecule called FGF21 rise significantly within five weeks, and this rise is closely tied to the increased calorie...
When lean, healthy men consume a diet with very low protein for five weeks while maintaining the same total calorie intake, they naturally eat more food to keep their weight stable, suggesting that...
In obese adults with type 2 diabetes, losing weight through diet and exercise improves blood sugar control, reduces body fat, and increases aerobic fitness, and these improvements continue for at...