Browse evidence-based analysis of health-related claims and assertions
These two trans fats interfere with how insulin tells blood vessels to relax by blocking key signals in the cell, but other fats don’t have this effect.
Mechanistic
A type of trans fat found naturally in dairy and meat doesn’t harm blood vessel cells in the lab, even though it looks similar to the harmful ones in fried foods.
Descriptive
These two harmful trans fats cause blood vessel cells to produce excess harmful oxygen molecules, which then trigger inflammation and block the production of a key chemical that keeps blood vessels healthy.
Two types of artificial trans fats found in fried and baked foods make blood vessel cells more inflamed and less able to produce a chemical that helps blood vessels relax, but a different trans fat found in dairy doesn’t do this.
We don’t know if natural trans fats from meat and dairy affect cancer risk — no solid human studies have looked at this yet.
Small experiments on ruminant trans fats and heart health markers haven't given clear answers — maybe because they used too few people or too much fat that you can't actually eat in real life.
Some studies suggest that the natural trans fats found in milk and meat might not raise heart disease risk the same way that artificial trans fats in fried and baked foods do.
Correlational
When you block cancer cells from storing these fats and/or push them into ferroptosis, the cancer-killing effect of n-3 and n-6 fats gets even stronger.
Feeding mice a diet high in certain healthy fats (n-3 PUFAs) made their tumors grow slower than feeding them a diet high in other fats like olive oil.
When tumors are acidic, certain healthy fats (n-3 and n-6) can kill cancer cells by causing a specific type of cell death called ferroptosis, especially if you block a storage mechanism in the cells.
Eating a lot of soybean oil for a month lowered levels of DHA — a healthy omega-3 fat — in red blood cells, possibly because the two types of fats compete to get into cell membranes.
Causal
Even though soybean oil is full of linoleic acid, it didn’t make the body’s enzymes that turn it into other fatty acids work faster — so it doesn’t lead to more inflammation as some fear.
People who ate soybean oil daily for a month tended to have slightly lower levels of a key inflammation signal called IL-6, though the result wasn’t strong enough to be certain.
After eating soybean oil daily for a month, the level of a fatty acid called arachidonic acid went down in red blood cells — which is surprising because people thought it would go up.
Eating snacks with 30g of soybean oil every day for a month doesn’t make your body more inflamed or damage your blood fats, even though some people say it does.
People who eat only meat for years usually have gut bacteria that break down protein, not plants—but sometimes, even without plants, their gut bugs still look like those of people who eat both meat and veggies.
Some humans have more copies of a gene that helps digest starch—this evolved in groups that ate a lot of tubers and grains, showing we didn’t just eat meat.
Humans can't digest plant fiber like cows do—we don't have the right enzymes. Instead, our gut bacteria do a little bit of breaking it down, which suggests our ancestors relied more on meat than plants for energy.
Human stomach acid is as strong as a lion’s—this helps us break down meat quickly and kill dangerous germs from eating raw or old animal flesh.
People who eat a lot of meat have specific chemicals in their blood—ketones, BCAAs, and TMAO—that show their bodies are burning fat for energy, breaking down protein, and their gut bacteria are processing meat in a unique way.
Humans have a gut that's shorter than herbivores' but longer than carnivores', which evolved to better digest meat and fat instead of plants, freeing up energy for our big brains.
Not all trans fats are the same — some dairy fats lower diabetes risk, one dairy fat raises it, and artificial trans fats don’t seem to matter at all. What matters most is the exact molecular shape, not whether it’s natural or artificial.
A fat called trans-palmitoleic acid was once thought to protect against diabetes, but when scientists accounted for other similar fats in dairy, the link disappeared — meaning the earlier belief was probably wrong.
The artificial trans fats found in fried foods and margarine don’t seem to raise the risk of type 2 diabetes when looked at on their own, which surprises many people who think all trans fats are bad.