Browse evidence-based analysis of health-related claims and assertions
In rats with heart injury from blocked blood flow, a lower dose of butyrate reduced the damaged area by 57.1%.
In rat hearts, butyrate at a higher dose increased blood flow through the heart's arteries by 20.9%.
In rats, butyrate made blood vessels wider, reducing resistance by 33.5% without changing blood pressure or heart rate.
In rats, butyrate caused blood vessels in the heart to relax more as the dose increased, with the most effective dose being 0.57 mM.
In rats with heart injury from blocked blood flow, butyrate at a certain dose reduced the damaged heart tissue by 81.7%.
In rat hearts outside the body, butyrate at a certain dose made the heart pump harder, increasing pressure by 14.1%.
In rats, giving butyrate at a certain concentration made the heart pump 48.8% more blood without changing blood pressure or heart rate.
The enzyme that makes blood pressure hormones increased in both kidneys of mice with high blood pressure, and PRO20 didn't stop this increase.
Mice with high blood pressure given PRO20 were able to excrete salt normally after a salt load, unlike untreated mice.
When given PRO20, mice with high blood pressure didn't show higher levels of a key blood pressure hormone in the non-clipped kidney.
In mice with high blood pressure, the sodium channel protein in the kidneys was more than double in both kidneys, but a drug called PRO20 reduced this increase to about 1.5 times and 1.2 times in the clipped and other kidney.
In mice with a specific type of high blood pressure model, the PRR protein in the kidneys was 4 times higher in the clipped kidney and 2 times higher in the other kidney compared to healthy mice.
In rats, a ketone body made the heart contract more forcefully, as shown by faster pressure changes in arteries.
In rat heart arteries, the ketone body relaxes blood vessels without needing the inner lining or certain inflammatory chemicals.
In rats, a ketone body reduced resistance in blood vessels without changing overall blood pressure.
Both versions of the ketone body (D and L) relaxed rat heart arteries equally, showing the effect doesn't depend on which version is used.
In rat veins, a ketone body relaxed different veins at different doses, with arm veins relaxing at lower doses than leg or gut veins.
In rat blood vessels, a ketone body relaxed heart, brain, leg, and gut arteries more easily than kidney arteries, with heart arteries responding at lower doses.
In rat heart arteries, a ketone body relaxed the blood vessels starting at low concentrations, with the strongest effect at higher doses.
When added to isolated rat hearts, a ketone body made the heart muscle contract more strongly and increased blood flow to the heart muscle itself.
In rats, a specific dose of a ketone body made the heart pump more blood per beat and overall without changing how fast the heart beats.
Blood pressure medications are more effective when combined with metabolic improvements (e.g., weight loss, whole-food diet, exercise, sleep) that restore hormonal regulation of sodium and vascular function.
Hypertension is primarily caused by processed foods that disrupt multiple regulatory mechanisms of blood pressure, rather than being solely a salt or sugar issue.
Salt restriction effectively lowers blood pressure in young, lean individuals with primary hypertension but has minimal effect in older patients with insulin resistance, obesity, or metabolic syndrome due to hormonal drivers.